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Our programs include the development of new synthetic transformations to chemically build and precisely modify proteins and oligonucleotides to produce new molecules with novel physicochemical properties and programmed activity for fundamental research and therapeutic applications. Our projects involve modern (bio)organic chemistry and chemical biology, such as solid-phase synthesis, combinatorial chemistry, late-stage transformations, and organometallic chemistry.

Research: Research

Protein Engineering

Nature has developed a plethora of protein machinery to operate and maintain nearly every task of cellular life. These processes are tightly regulated via post-expression modifications—transformations that modulate intracellular protein synthesis, folding, and activation. Methods to prepare homogeneously and precisely modified proteins are essential to probe their function and design new bioactive modalities.

Our lab is interested in the development of new synthetic strategies to generate new proteins with novel physicochemical properties and programmed activity for basic research and biomedical applications.

O. Harel and M. Jbara, Angew. Chem. Int. Ed., 2023, 62, e202217716

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