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Publications: Publications
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33. Chemical Engineering of Artificial Transcription Factors by Orthogonal Palladium(II)-Mediated S-Arylation Reactions

Xiaoxi Lin, Omer Harel and Muhammad Jbara*

Angewandte Chemie International Edition, 2024, 63, e202317511

(Selected as a Hot Paper)

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32. Deciphering the Role of the Ser-Phosphorylation Pattern on the DNA-Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis

Raj V. Nithun, Yumi Minyi Yao, Xiaoxi Lin, Shaimaa Habiballah, Ariel Afek*, and Muhammad Jbara*

Angewandte Chemie International Edition, 2023, 62, e202310913

(Selected as a Very Important Paper)

(Highlighted as a Front Cover)

(Highlighted in Doctors & TAU-School of Chemistry websites)


31. Enabling Peptide Ligation at Aromatic Junction Mimics via Native Chemical Ligation and Palladium-Mediated S-Arylation

Xiaoxi Lin, Raj V Nithun, Raju Samanta, Omer Harel, and Muhammad Jbara*

Organic Letters, 2023, 25, 4715–4719


30. Chemical Synthesis of Bioactive Proteins 

Omer Harel and Muhammad Jbara*

Angewandte Chemie International Edition, 2023, 62, e202217716


29. Histone H3 Serine-57 is a CHK1 Substrate Whose Phosphorylation Affects DNA Repair

Nikolaos Parisis, Pablo Dans Puigrὸs, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Diego Molina-Serrano, Isabelle Brun Heath, Denisa Hendrychova, Suman Kumar Maity, Diana Buitrago, Rafael Lema, Thiziri Nait Achour, Simona Giunta, Michael Girardot, Nicolas Talarek, Valérie Rofidal, Katerina Danezi, Damien Coudreuse, Marie-Noëlle Prioleau, Robert Feil, Modesto Orozco, Ashraf Brik, Pei-Yun Jenny Wu, Liliana Krasinska, Daniel Fisher*

Nature Communications, 2023, 14, 5104

Image by Hassaan Here

28. Peptide and Protein Chemistry: Design, Synthesis, and Applications

Muhammad Jbara


27. Posttranslational Chemical Mutagenesis Methods to Insert Posttranslational Modifications into Recombinant Proteins

Omer Harel and Muhammad Jbara*

Molecules, 2022, 27(14), 4389

(Invited Paper)


26. Transition Metal Catalyzed Site-Selective Cysteine Diversification of Proteins

Muhammad Jbara* 

Pure and Applied Chemistry, 2021, 93, 169–186

(Invited Paper)


25. Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents

Muhammad Jbara,† Sebastian Pomplun,† Carly K Schissel, Susana W Hawken, Ann Boija, Isaac Klein, Jacob Rodriguez, Stephen L Buchwald, and Bradley L Pentelute*

Journal of the American Chemical Society, 2021, 143, 11788–11798


24. Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents

Muhammad Jbara, Jacob Rodriguez, Heemal H Dhanjee, Andrei Loas, Stephen L Buchwald,* and Bradley L Pentelute*

Angewandte Chemie International Edition, 2021, 60, 12109-12115

(Selected by the Editor as a Hot Paper)


23. Parallel automated flow synthesis of covalent protein complexes that can inhibit MYC-driven transcription

Sebastian Pomplun,† Muhammad Jbara,† Carly K Schissel, Susana W Hawken, Ann Boija, Charles Li, Isaac Klein, and Bradley L Pentelute*

ACS Central Science, 2021, 7, 8, 1408-1418

(Highlighted as Supplementary Cover)


22. De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

Sebastian Pomplun, Muhammad Jbara, Anthony J Quartararo, Genwei Zhang, Joseph S Brown, Yen-Chun Lee, Xiyun Ye, Stephanie Hanna, and Bradley L Pentelute*

ACS Central Science, 2021, 7, 156–163

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21. Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation

Muhammad Jbara,† Emad Eid,† and Ashraf Brik*

Journal of the American Chemical Society, 2020, 142, 8203–8210

Journal of the American Chemical Society, 2020, 142, 8203–8210

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20. Examining Several Strategies for the Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach

Muhammad Jbara, Suman K Maity, and Ashraf Brik*

European Journal of Organic Chemistry, 2020, 21, 3128-3132

(Selected by the Editor as a Very Important Paper)


19. Semi-synthesis of Ubiquitinated Histone H2B with a Native or Non-hydrolyzable Linkage

Michael Morgan, Muhammad Jbara, Ashraf Brik, and Cynthia Wolberger* 

Methods in Enzymology, 2019, 618, 1-27


18. FACT and Ubp10 Collaborate to Modulate H2B Deubiquitination and Nucleosome Dynamics

Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara, Hao Sun, Ashraf Brik, Tim Formosa*, and Cynthia Wolberger*

eLife, 2019, 8, e40988



17. Chemical Chromatin Ubiquitylation

Muhammad Jbara, Hao Sun, Guy Kamnesky, and Ashraf Brik* 

Current Opinion in Chemical Biology, 2018, 45, 18–26


16. Palladium Mediated Deallylation in Fully Aqueous Conditions for Native Chemical Ligation at Aspartic and Glutamic Acid Sites

Muhammad Jbara, Emad Eid, and Ashraf Brik* 

Organic & Biomolecular Chemistry, 2018, 16, 4061-4064


15. Palladium Prompted On-Demand Orthogonal Cysteine Chemistry for the Synthesis of Challenging and Uniquely Modified Proteins

Muhammad Jbara,† Shay Laps,† Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, and Ashraf Brik*

Nature Communications, 2018, 9, 3154

(Featured in Nature Communications Editors' Highlights)



14. Total Chemical Synthesis of Methylated Analogues of Histone 3 Revealed KDM4D as a Potential Regulator of H3K79me3

Muhammad Jbara, Noga Guttmann-Raviv, Suman K Maity, Nabieh Ayoub*, and Ashraf Brik*

Bioorganic & Medicinal Chemistry, 2017, 18, 4966-4970


13. Palladium in the Chemical Synthesis and Modification of Proteins

Muhammad Jbara, Suman K Maity, and Ashraf Brik*

Angewandte Chemie International Edition, 2017, 56, 10644–10655


12. Total Chemical Synthesis of Histones and their Analogues Assisted by Native Chemical Ligation and Palladium Complexes

Suman K Maity, Muhammad Jbara, Guy Mann, Guy Kamnesky, and Ashraf Brik*

Nature Protocols, 2017, 12, 2293–2322



11. Palladium Assisted Cleavage of Peptides and Proteins Containing a Backbone Thiazolidine Linkage

Muhammad Jbara, Shay Laps, Suman K Maity, and Ashraf Brik*

Chemistry–A European Journal, 2016, 22, 14851–14855

(Selected by the Editor as a Hot Paper)


10. Palladium Assisted Rapid Removal of a Solubilizing Tag from a Cys Side Chain to Facilitate Peptide and Protein Synthesis. 

Suman K Maity, Guy Mann, Muhammad Jbara, Shay Laps, Guy Kamnesky, and Ashraf Brik*

Organic Letters, 2016, 18, 3026–3029

(ACS Editors' Choice)


9. Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization to Expedite Chemical Protein Synthesis

Suman K Maity,† Muhammad Jbara,† Shay Laps, and Ashraf Brik*

Angewandte Chemie International Edition, 2016, 55, 8108–8112


8. Palladium Mediated Rapid Deprotection of N-terminal Cysteine Under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins

Muhammad Jbara,† Suman K Maity,† Mallikanti Seenaiah, and Ashraf Brik*

Journal of the American Chemical Society, 2016, 138, 5069-5075


7. Expanding the Chemical Toolbox for the Synthesis of Large and Unique Proteins

Somasekhar Bondalapati,† Muhammad Jbara,† and Ashraf Brik*

Nature Chemistry, 2016, 8, 407-418


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6. Chemical and Semisynthesis of Modified Histones

Suman K Maity, Muhammad Jbara, and Ashraf Brik*

Journal of Peptide Science, 2016, 22, 252-259


5. Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module

Muhammad Jbara, Suman K Maity, Michael Morgan, Cynthia Wolberger, and Ashraf Brik*

Angewandte Chemie International Edition, 2016, 55, 4972–4976


4. Convergent vs. Linear Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B 

Mallikanti Seenaiah, Muhammad Jbara, Sachitanand M Mali, and Ashraf Brik*

Angewandte Chemie International Edition, 2015, 54, 12374-12378

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3. The Ubiquitin Ligase KPC1 Promotes Processing of p105 NF-KB1 to p50, Resulting in Strong Tumor Suppression

Yelena Kravtsova-Ivantsiv, Inna Shomer, Victoria Cohen-Kaplan, Berend Snijder, Giulio Superti-Furga, Hedva Gonen, Thomas Sommer, Tamar Ziv, Arie Admon, Inna Naroditsky, Muhammad Jbara, Ashraf Brik, Eli Pikarsky, Yong Tae Kwon, Ilana Doweck, and Aaron Ciechanover*

Cell, 2015, 161, 333–347


2. Solid Phase Chemical Ligation Employing a Rink Amide Linker for the Synthesis of Histone H2B Protein

Muhammad Jbara, Mallikanti Seenaiah, and Ashraf Brik* 

Chemical Communications, 2014, 50, 12534-12537

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1. Modifying the Vicinity of the Isopeptide Bond to Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins: Organic Chemistry Applied to Synthetic Proteins

Najat Haj‐Yahya, Mahmood Haj‐Yahya, Carlos A Castañeda, Liat Spasser, Hosahalli P Hemantha, Muhammad Jbara, Marlin Penner, Aaron Ciechanover, David Fushman, and Ashraf Brik*

Angewandte Chemie International Edition, 2013,  52, 11149-11153

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